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    An estimated 10 million to 20 million American men have some degree of erectile dysfunction, the incidence of which increases markedly with age. Between the ages of 40 and 70 years, the probability of complete erectile dysfunction triples from 5.1 percent to 15 percent.1 SOURCE: Sleep, January 2010. Erectile dysfunction isn't easy to talk about. Yet some 5% of 40-year-old men and up to 25% of 65-year-old men experience ED. WebMD's experts use plain, explicit language to give you information on erectile dysfunction causes, tests, treatments, and support. Here's where you and your partner can start building a better sex life. Your doctor may recommend antidepressants called selective serotonin reuptake inhibitors (SSRIs). Also, natural PMS remedies include yoga, exercise, and herbs such as black cohosh, chasteberry, dandelion and evening primrose oil. Sexual dysfunction Sexual dysfunction or sexual malfunction is difficulty during any stage of the sexual ... > read more Some men, however, experience chronic, complete erectile dysfunction (impotence), and others, partial or brief erections. Frequent erectile dysfunction can cause emotional and relationship problems, and often leads to diminished self-esteem. Erectile dysfunction has many causes, most of which are treatable, and is not an inevitable consequence of aging. Hormonal (testosterone) therapy No surgery required Inexpensive Pellet must be inserted directly into penis through urethral opening Monitoring erections that occur during sleep (nocturnal penile tumescence) can help distinguish between erectile dysfunction of psychological and physical causes. If nocturnal erections do not occur, then the cause of erectile dysfunction is likely to be physical rather than psychological, however, tests of nocturnal erections are not completely reliable. Scientists have not standardized the tests and have not determined in whom they should be done. Recent stroke or heart attack (within 6 months) Alcohol and Erectile Dysfunction Erectile dysfunction (ED), also known as impotence, is the inability to achieve or sustain an erection for satisfactory sexual activity. Canadian Viagra online CYP4503A4 inhibitors (eg, erythromycin, ketoconazole, itraconazole, indinavir, ritonavir) may significantly increase levels; potentiates hypotensive effect of nitrates or alpha-blockers; avoid coadministration with other drugs that prolong QT interval (eg, quinidine, procainamide, amiodarone, sotalol) How Is Erectile Dysfunction Treated? A. I start most of my patients with Caverject (alprostadil), also called prostaglandin. This 1995 FDA-approved prescription drug comes in two strengths in a disposable, single-dose syringe that's pre-filled with the erection-enhancing medication. Injected directly into the base of the penis five minutes before a sexual encounter, the drug increases blood flow and produces an erection. Caverject is much more readily available than trimix (you need a pharmacy with a compounding license for this preparation). Many men like the convenience of Caverject. It doesn't need to refrigerated and it's easier to transport. Penile biothesiometryThis test uses electromagnetic vibration to evaluate sensitivity and nerve function in the glands and shaft of the penis. A decreased perception of vibration may indicate nerve damage in the pelvic area, which can lead to impotence. Research into the structure, function, and regulation of PDEs has progressed a long way from the initial identification of PDE activity nearly 50 years ago. The PDE enzymes are now well recognized to be important regulators of many different cellular functions. Research in the field has evolved from early studies primarily concerning identification of PDE enzymes and characterization of their kinetic and regulatory properties to more recent work on their structure and how their activities are regulated in the cellular context. This accumulation of basic knowledge should further foster the targeting of these enzymes for drug development and clinical treatment.

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